Hours Of Operations Home Depot South Carolina Lancaster Home Depot Hours of Operation and Locations in Lancaster, SC 4.9 - 147 votes 1 Locations in Lancaster Home Depot Hours Category: Home & Garden Home Depot - Lancaster, SC 29720 1116 Highway 9 Byp W(803) 286-9700 View Store Details Explore LancasterView More Apparel Big LotsGoody'sCatoHamrick'sCarhartt Sports Sport CenterG Sports Jewelry CatoBelk Recommend For You CVS Target IKEA Michaels Costco Marshalls Sports Authority Walgreens Publix Great Clips