Hours Of Operations Home Depot South Carolina Spartanburg Home Depot Hours of Operation and Locations in Spartanburg, SC 4.9 - 147 votes 2 Locations in Spartanburg Home Depot Hours Category: Home & Garden Home Depot - Spartanburg, SC 29307 2300 E Main St(864) 579-0382 View Store Details Home Depot - Spartanburg, SC 29301 121 Dorman Centre Dr(864) 574-2922 View Store Details Explore SpartanburgView More Apparel Sam's ClubCostcoMarshallsTJ MaxxRoss Dress for Less Sports CostcoTargetDick's Sporting GoodsAdidasColeman Jewelry Sam's ClubCostcoMarshallsHobby LobbyBurlington Coat Factory Recommend For You CVS Target IKEA Michaels Costco Marshalls Sports Authority Walgreens Publix Great Clips